A novel 2H-azirin-3-amine as a synthon for a sulfur containing dipeptide segment
نویسندگان
چکیده
Starting with tetrahydro-2H-thiopyran-4-carboxylic acid and methyl prolinate, the novel 2Hazirin-3-amine (S)-N-(1-aza-6-thiaspiro[2.5]oct-1-en-2-yl)proline methyl ester was synthesized. In reactions with benzoic acid, thiobenzoic acid and Boc-valine, respectively, its usefulness as a synthon for the dipeptide (S)-N-[(4-aminotetrahydro-2H-thiopyran-4-yl)carbonyl]proline in peptide synthesis was demonstrated. DOI: https://doi.org/10.1080/17415993.2013.774401 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-78018 Accepted Version Originally published at: Stoykova, Svetlana A; Linden, Anthony; Heimgartner, Heinz (2014). A novel 2H-azirin-3-amine as a synthon for a sulfur containing dipeptide segment. Journal of Sulfur Chemistry, 35(1):14-23. DOI: https://doi.org/10.1080/17415993.2013.774401
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